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1

Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action

Hossein Razavi, Satheesh K. Palaninathan, Evan T. Powers, R. Luke Wiseman, Hans E. Purkey, Nilofar N. Mohamedmohaideen, Songpon Deechongkit, Kyle P. Chiang, Maria T. A. Dendle, James C. Sacchettini, J

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 149 KB

english, 2003

2

Crystal structure of a plant catechol oxidase containing a dicopper center

Klabunde, Thomas, Eicken, Christoph, Sacchettini, James C., Krebs, Bernt

Journal:

Natural Structural Biology

Year:

1998

Language:

english

File:

PDF, 1.09 MB

english, 1998

3

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

Sun, Qingan, Li, Xiaojun, Perez, Lisa M., Shi, Wanliang, Zhang, Ying, Sacchettini, James C.

Journal:

Nature Communications

Year:

2020

Language:

english

File:

PDF, 1.77 MB

english, 2020

4

Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis

Joel S. Freundlich, Feng Wang, Catherine Vilchèze, Gulcin Gulten, Robert Langley, Guy A. Schiehser, David P. Jacobus, William R. Jacobs Jr., James C. Sacchettini

Journal:

Year:

2009

Language:

english

File:

PDF, 698 KB

english, 2009

5

Structural genomics approach to drug discovery for Mycobacterium tuberculosis

Thomas R Ioerger, James C Sacchettini

Journal:

Current Opinion in Microbiology

Year:

2009

Language:

english

File:

PDF, 1.94 MB

english, 2009

6

Redefining the Role of the Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase

Mosser, Rockann, Reddy, Manchi C. M., Bruning, John B., Sacchettini, James C., Reinhart, Gregory D.

Journal:

Year:

2013

Language:

english

File:

PDF, 395 KB

english, 2013

7

Reversible Ligand-Induced Dissociation of a Tryptophan-Shift Mutant of Phosphofructokinase from Bacillus stearothermophilus †,‡

Riley-Lovingshimer, Michelle R., Ronning, Donald R., Sacchettini, James C., Reinhart, Gregory D.

Journal:

Year:

2002

Language:

english

File:

PDF, 207 KB

english, 2002

8

Kinetic and Structural Characterization of Phosphofructokinase from Lactobacillus bulgaricus †

Paricharttanakul, N. Monique, Ye, Sheng, Menefee, Ann L., Javid-Majd, Farah, Sacchettini, James C., Reinhart, Gregory D.

Journal:

Year:

2005

Language:

english

File:

PDF, 298 KB

english, 2005

9

A General Method for Facilitating Heterodimeric Pairing Between Two Proteins: Application to Expression of α and β T-Cell Receptor Extracellular Segments

Hsiu-Ching Chang, Zheng-Zheng Bao, Yasuko Yao, Albert G. D. Tse, Earl C. Goyarts, Mari Madsen, Ernest Kawasaki, Pamela P. Brauer, James C. Sacchettini, Stanley G. Nathenson and Ellis L. Reinherz

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.25 MB

english, 1994

10

Structure-guided design of a potent peptide-inhibitor targeting the interaction between CRK and ABL kinase

Shen, Qingliang, Bhatt, Veer S, Krieger, Inna, Sacchettini, James C, Cho, Jae-Hyun

Journal:

Year:

2018

Language:

english

File:

PDF, 1.15 MB

english, 2018

11

R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold

Salazar, Adam J., Sherekar, Mukul, Tsai, Jennifer, Sacchettini, James C., Mayans, Olga

Journal:

Year:

2019

Language:

english

File:

PDF, 3.58 MB

english, 2019

12

Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action

Hossein Razavi, Satheesh K. Palaninathan, Evan T. Powers, R. Luke Wiseman, Hans E. Purkey, Nilofar N. Mohamedmohaideen, Songpon Deechongkit, Kyle P. Chiang, Maria T. A. Dendle, James C. Sacchettini, J

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 149 KB

english, 2003

13

Hydroxylated Polychlorinated Biphenyls Selectively Bind Transthyretin in Blood and Inhibit Amyloidogenesis: Rationalizing Rodent PCB Toxicity

Hans E. Purkey, Satheesh K. Palaninathan, Kathleen C. Kent, Craig Smith, Stephen H. Safe, James C. Sacchettini, Jeffery W. Kelly

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

14

Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids

Hector R. Morbidoni, Catherine Vilchèze, Laurent Kremer, Robert Bittman, James C. Sacchettini, William R. Jacobs Jr.

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 443 KB

english, 2006

15

Identification of a Type III Thioesterase Reveals the Function of an Operon Crucial for Mtb Virulence

Feng Wang, Robert Langley, Gulcin Gulten, Lei Wang, James C. Sacchettini

Journal:

Chemistry & Biology

Year:

2007

Language:

english

File:

PDF, 756 KB

english, 2007

16

Mycolic Acid Cyclopropanation is Essential for Viability, Drug Resistance, and Cell Wall Integrity of Mycobacterium tuberculosis

Daniel Barkan, Zhen Liu, James C. Sacchettini, Michael S. Glickman

Journal:

Chemistry & Biology

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

17

Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities

Anna C. Giddens, Lone Nielsen, Helena I. Boshoff, Deniz Tasdemir, Remo Perozzo, Marcel Kaiser, Feng Wang, James C. Sacchettini, Brent R. Copp

Journal:

Year:

2008

Language:

english

File:

PDF, 274 KB

english, 2008

18

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

Michelle H. Larsen, Catherine Vilchèze, Laurent Kremer, Gurdyal S. Besra, Linda Parsons, Max Salfinger, Leonid Heifets, Manzour H. Hazbon, David Alland, James C. Sacchettini, William R. Jacobs Jr

Journal:

Molecular Microbiology

Year:

2002

Language:

english

File:

PDF, 296 KB

english, 2002

19

Solution structure of ileal lipid binding protein in complex with glycocholate

Christian Lücke, Fengli Zhang, James A. Hamilton, James C. Sacchettini, Heinz Rüterjans

Journal:

Year:

2000

Language:

english

File:

PDF, 804 KB

english, 2000

20

Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein

Nishant D. Shetty, Manchi C. M. Reddy, Satheesh K. Palaninathan, Joshua L. Owen, James C. Sacchettini

Journal:

Protein Science

Year:

2010

Language:

english

File:

PDF, 601 KB

english, 2010

21

Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site

Arulandu Arockiasamy, Anup Aggarwal, Christos G. Savva, Andreas Holzenburg, James C. Sacchettini

Journal:

Protein Science

Year:

2011

Language:

english

File:

PDF, 285 KB

english, 2011

22

13C NMR studies of fatty acid-protein interactions: comparison of homologous fatty acid-binding proteins produced in the intestinal epithelium

David P. Cistola, James C. Sacchettini, Jeffrey I. Gordon

Journal:

Molecular and Cellular Biochemistry

Year:

1990

Language:

english

File:

PDF, 729 KB

english, 1990

23

Expression of rat intestinal fatty acid binding protein inE. coliand its subsequent structural analysis: a model system for studying the molecular details of fatty acid-protein interaction

James C. Sacchettini, Leonard J. Banaszak, Jeffrey I. Gordon

Journal:

Molecular and Cellular Biochemistry

Year:

1990

Language:

english

File:

PDF, 1.02 MB

english, 1990

24

High resolution X-ray studies of mammalian intestinal and muscle fatty acid-binding proteins provide an opportunity for defining the chemical nature of fatty acid: protein interactions

Giovanna Scapin, Aideen C. M. Young, Arno Kromminga, Jacques H. Veerkamp, Jeffrey I. Gordon, James C. Sacchettini

Journal:

Molecular and Cellular Biochemistry

Year:

1993

Language:

english

File:

PDF, 825 KB

english, 1993

25

Structural basis of fumarate hydratase deficiency

Sarah Picaud, Kathryn L. Kavanagh, Wyatt W. Yue, Wen Hwa Lee, Susanne Muller-Knapp, Opher Gileadi, James Sacchettini, Udo Oppermann

Journal:

Journal of Inherited Metabolic Disease

Year:

2011

Language:

english

File:

PDF, 323 KB

english, 2011

26

1H,13C and15N Chemical Shift Assignments of the C-Terminal, 133-Residue Pseudo-Receiver Domain of Circadian Input Kinase (CikA) inSynechococcus elongatus

Tiyu Gao, Xiaofan Zhang, Youlin Xia, Yoonsang Cho, James C. Sacchettini, Susan S. Golden, Andy C. LiWang

Journal:

Journal of Biomolecular NMR

Year:

2005

Language:

english

File:

PDF, 178 KB

english, 2005

27

M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs)

Róisín M. Owens, Fong Fu Hsu, Brian C. VanderVen, Georgiana E. Purdy, Elizabeth Hesteande, Peter Giannakas, James C. Sacchettini, John D. McKinney, Preston J. Hill, John T. Belisle, Barbara A. Butcher

Journal:

Molecular Microbiology

Year:

2006

Language:

english

File:

PDF, 778 KB

english, 2006

28

Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis

Ty A. Gould, Helmus Van De Langemheen, Ernesto J. Muñoz-Elías, John D. McKinney, James C. Sacchettini

Journal:

Molecular Microbiology

Year:

2006

Language:

english

File:

PDF, 262 KB

english, 2006

29

Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis

Catherine Vilchèze, Yossef Av-Gay, Rodgoun Attarian, Zhen Liu, Manzour H. Hazbón, Roberto Colangeli, Bing Chen, Weijun Liu, David Alland, James C. Sacchettini, William R. Jacobs Jr

Journal:

Molecular Microbiology

Year:

2008

Language:

english

File:

PDF, 685 KB

english, 2008

30

Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase

Kimberly Payne, Qingan Sun, James Sacchettini, Graham F. Hatfull

Journal:

Molecular Microbiology

Year:

2009

Language:

english

File:

PDF, 861 KB

english, 2009

31

Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis

Virginie Molle, Gulcin Gulten, Catherine Vilchèze, Romain Veyron-Churlet, Isabelle Zanella-Cléon, James C. Sacchettini, William R. Jacobs Jr, Laurent Kremer

Journal:

Molecular Microbiology

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

32

Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa)

Xiaomin Cai, A. Lorraine Fuller, Larry R. McDougald, Xiangshi Tan, Jianping Cai, Feng Wang, James C. Sacchettini, Guan Zhu

Journal:

FEMS Microbiology Letters

Year:

2007

Language:

english

File:

PDF, 290 KB

english, 2007

33

Identification of differentially regulated gene targets in the Myc and Mad family proteins

O'Hagan, Ronan, Schreiber-Agus, Nicole, Engelman, Jeffrey A., Schwab, Richard, Alland, Leila, Thompson, Cole, Ronning, Donald R., Sacchettini, James C., Meltzer, Paul, DePinho, Ronald A.

Journal:

Nature Genetics

Year:

1999

Language:

english

File:

PDF, 90 KB

english, 1999

34

10.1038/35021074

McKinney, John D., zu Bentrup, Kerstin Höner, Muñoz-Elías, Ernesto J., Miczak, Andras, Chen, Bing, Chan, Wai-Tsing, Swenson, Dana, Sacchettini, James C., Jacobs, William R., Russell, David G.

Journal:

Year:

2000

Language:

english

File:

PDF, 236 KB

english, 2000

35

10.1038/72413

Sacchettini, James C., Ronning, Donald R., Klabunde, Thomas, Besra, Gurdyal S., Vissa, Varalakshmi D., Belisle, John T.

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 533 KB

english, 2000

36

Gene-target recognition among members of the Myc superfamily and implications for oncogenesis

O'Hagan, Rónán C., Schreiber-Agus, Nicole, Chen, Ken, David, Gregory, Engelman, Jeffrey A., Schwab, Richard, Alland, Leila, Thomson, Cole, Ronning, Donald R., Sacchettini, James C.

Journal:

Nature Genetics

Year:

2000

Language:

english

File:

PDF, 1.04 MB

english, 2000

37

10.1038/74082

Sacchettini, James C., Klabunde, Thomas, Petrassi, H. Michael, Oza, Vibha B., Raman, Prakash, Kelly, Jeffery W.

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 1.73 MB

english, 2000

38

10.1038/77964

Sharma, Vivek, Sharma, Sujata, zu Bentrup, Kerstin Hoener, McKinney, John D., Russell, David G., Jacobs, William R., Sacchettini, James C.

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 516 KB

english, 2000

39

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway

Jacobs, William R, Bornemann, Stephen, Kalscheuer, Rainer, Syson, Karl, Veeraraghavan, Usha, Weinrick, Brian, Biermann, Karolin E, Liu, Zhen, Sacchettini, James C, Besra, Gurdyal

Journal:

Nature Chemical Biology

Year:

2010

Language:

english

File:

PDF, 909 KB

english, 2010

40

CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator

Liu, Tong, Ramesh, Arati, Ma, Zhen, Ward, Sarah K, Zhang, Limei, George, Graham N, Talaat, Adel M, Sacchettini, James C, Giedroc, David P

Journal:

Nature Chemical Biology

Year:

2006

Language:

english

File:

PDF, 590 KB

english, 2006

41

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

Ford, Christopher B, Lin, Philana Ling, Chase, Michael R, Shah, Rupal R, Iartchouk, Oleg, Galagan, James, Mohaideen, Nilofar, Ioerger, Thomas R, Sacchettini, James C, Lipsitch, Marc

Journal:

Nature Genetics

Year:

2011

Language:

english

File:

PDF, 784 KB

english, 2011

42

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid

Vilchèze, Catherine, Wang, Feng, Arai, Masayoshi, Hazbón, Manzour Hernando, Colangeli, Roberto, Kremer, Laurent, Weisbrod, Torin R, Alland, David, Sacchettini, James C, Jacobs, William R

Journal:

Nature Medicine

Year:

2006

Language:

english

File:

PDF, 251 KB

english, 2006

43

THERAPEUTIC STRATEGIES FOR HUMAN AMYLOID DISEASES

Sacchettini, James C., Kelly, Jeffery W.

Journal:

Nature Reviews Drug Discovery

Year:

2002

Language:

english

File:

PDF, 1.93 MB

english, 2002

44

Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis

Sacchettini, James C., Rubin, Eric J., Freundlich, Joel S.

Journal:

Nature Reviews Microbiology

Year:

2008

Language:

english

File:

PDF, 814 KB

english, 2008

45

Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing

Klabunde, Thomas, Sharma, Sujata, Telenti, Amalio, Jacobs, William R., Sacchettini, James C.

Journal:

Natural Structural Biology

Year:

1998

File:

PDF, 1.03 MB

1998

46

Regulation of a muralytic enzyme by dynamic membrane topology

Sun, Qingan, Kuty, Gabriel F, Arockiasamy, Arulandu, Xu, Min, Young, Ry, Sacchettini, James C

Journal:

Nature Structural and Molecular Biology

Year:

2009

Language:

english

File:

PDF, 627 KB

english, 2009

47

Charged residue changes in the carboxy-terminus of α-tropomyosin alter mouse cardiac muscle contractility

Robert D. Gaffin, Kuppan Gokulan, James C. Sacchettini, Timothy Hewett, Raisa Klevitsky, Jeffrey Robbins, Mariappan Muthuchamy

Journal:

The Journal of Physiology

Year:

2004

Language:

english

File:

PDF, 600 KB

english, 2004

48

A comparative study of the backbone dynamics of two closely related lipid binding proteins: Bovine heart fatty acid binding protein and porcine ileal lipid binding protein

Christian Lücke, David Fushman, Christian Ludwig, James A. Hamilton, James C. Sacchettini, Heinz Rüterjans

Journal:

Molecular and Cellular Biochemistry

Year:

1999

Language:

english

File:

PDF, 112 KB

english, 1999

49

Solution structure of human intestinal fatty acid binding protein: Implications for ligand entry and exit

Fengli Zhang, Christian Lücke, Leslie J. Baier, James C. Sacchettini, James A. Hamilton

Journal:

Journal of Biomolecular NMR

Year:

1997

Language:

english

File:

PDF, 2.90 MB

english, 1997

50

Kinetic Mechanism of Human Hypoxanthine−Guanine Phosphoribosyltransferase: Rapid Phosphoribosyl Transfer Chemistry†

Xu, Yiming, Eads, Janina, Sacchettini, James C., Grubmeyer, Charles

Journal:

Year:

1997

Language:

english

File:

PDF, 402 KB

english, 1997